Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 603)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0946773	0.0998206	0.3536757
Weighted median	23	-0.0488957	0.0551560	0.3753489
Inverse variance weighted	23	-0.0224155	0.0390157	0.5656134
Simple mode	23	-0.0855567	0.0960361	0.3826334
Weighted mode	23	-0.0631609	0.0666938	0.3539114

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.61588	21	0.7341116
Inverse variance weighted	17.23443	22	0.7502922

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044376	0.0056423	0.4403709

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005323	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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