Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 602)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1296544	0.0998200	0.2080660
Weighted median	23	0.0466945	0.0570107	0.4127587
Inverse variance weighted	23	0.0556399	0.0390156	0.1538418
Simple mode	23	0.0847653	0.0954808	0.3842661
Weighted mode	23	0.0431791	0.0658375	0.5187256

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.65239	21	0.6708828
Inverse variance weighted	21.71953	22	0.4767322

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0113789	0.0056423	0.0566922

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007198	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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