Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 601)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0908167	0.1005565	0.3766946
Weighted median	23	-0.0083750	0.0651549	0.8977221
Inverse variance weighted	23	-0.0410611	0.0402131	0.3072129
Simple mode	23	-0.2034567	0.1296486	0.1308518
Weighted mode	23	0.0518399	0.0986801	0.6046068

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.31135	21	0.4400761
Inverse variance weighted	23.37158	22	0.3810086

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0080987	0.005684	0.1689011

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007418	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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