Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 60)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0946691	0.0998201	0.3537145
Weighted median	23	-0.0994828	0.0531493	0.0612396
Inverse variance weighted	23	-0.0704862	0.0390157	0.0708228
Simple mode	23	-0.0280786	0.0825210	0.7368880
Weighted mode	23	-0.0709037	0.0663930	0.2971273

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.22143	21	0.6975990
Inverse variance weighted	17.29071	22	0.7471169

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014851	0.0056423	0.7949591

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006229	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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