Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 6)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0573791	0.1313142	0.6666002
Weighted median	23	-0.0632045	0.0571740	0.2689534
Inverse variance weighted	23	-0.0090714	0.0503355	0.8569800
Simple mode	23	-0.0583691	0.0913430	0.5294140
Weighted mode	23	-0.0847142	0.0674241	0.2221357

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.34224	21	0.0200063
Inverse variance weighted	36.61868	22	0.0260373

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029666	0.0074225	0.6934341

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011111	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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