Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 599)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0729132	0.1508929	0.6339455
Weighted median	23	0.0331492	0.0568091	0.5595446
Inverse variance weighted	23	0.0112914	0.0581239	0.8459688
Simple mode	23	-0.1261429	0.0990270	0.2160195
Weighted mode	23	0.0423272	0.0581114	0.4740639

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.98725	21	0.0006904
Inverse variance weighted	48.82717	22	0.0008427

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005171	0.0085291	0.5508334

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014819	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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