Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 598)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0938629	0.1306252	0.4803274
Weighted median	23	-0.1557442	0.0592532	0.0085775
Inverse variance weighted	23	-0.0131666	0.0504143	0.7939623
Simple mode	23	-0.1460396	0.1027533	0.1692605
Weighted mode	23	-0.1537473	0.0746784	0.0515473

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.96253	21	0.0220781
Inverse variance weighted	36.73394	22	0.0252955

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049556	0.0073836	0.5094345

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011165	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8