Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 597)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1004964	0.0998203	0.3255043
Weighted median	23	0.0033546	0.0570132	0.9530807
Inverse variance weighted	23	-0.0469742	0.0395954	0.2354828
Simple mode	23	-0.2062925	0.1008554	0.0529540
Weighted mode	23	-0.0062029	0.0651531	0.9250134

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.08277	21	0.5160243
Inverse variance weighted	22.65892	22	0.4211984

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0090561	0.0056423	0.1234194

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007306	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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