Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 596)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0550949	0.0998202	0.5868150
Weighted median	23	0.0848090	0.0537772	0.1147854
Inverse variance weighted	23	0.0571978	0.0390155	0.1426404
Simple mode	23	0.0707009	0.0832194	0.4047134
Weighted mode	23	0.0847240	0.0617573	0.1839282

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.13511	21	0.7028842
Inverse variance weighted	17.13563	22	0.7558317

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001291	0.0056423	0.9819561

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005844	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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