Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 595)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1386010	0.0998210	0.1795395
Weighted median	23	0.0129627	0.0537072	0.8092773
Inverse variance weighted	23	0.0085299	0.0390158	0.8269414
Simple mode	23	0.0285480	0.0825816	0.7328560
Weighted mode	23	0.0318416	0.0583010	0.5904529

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.46740	21	0.6824137
Inverse variance weighted	19.47149	22	0.6160617

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0079876	0.0056423	0.1715362

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005915	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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