Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 594)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0109427	0.1056265	0.9184713
Weighted median	23	0.0672417	0.0539897	0.2129646
Inverse variance weighted	23	0.0387539	0.0404144	0.3376031
Simple mode	23	0.0882763	0.0822689	0.2948914
Weighted mode	23	0.0744637	0.0583300	0.2150579

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.51421	21	0.3171863
Inverse variance weighted	23.60583	22	0.3682246

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017079	0.0059705	0.7776406

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007452	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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