Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 593)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1559702	0.1025321	0.1431295
Weighted median	23	0.0436775	0.0571710	0.4448793
Inverse variance weighted	23	0.0158220	0.0411584	0.7006693
Simple mode	23	0.1188772	0.0847363	0.1746001
Weighted mode	23	0.0608216	0.0614486	0.3330360

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.15638	21	0.3905467
Inverse variance weighted	24.48304	22	0.3224284

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086065	0.0057956	0.1524013

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007469	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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