Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 592)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0643994	0.1380223	0.6455997
Weighted median	23	-0.0224560	0.0601984	0.7091243
Inverse variance weighted	23	0.0329309	0.0527841	0.5327074
Simple mode	23	0.1521558	0.1065187	0.1672089
Weighted mode	23	-0.0670179	0.0740221	0.3750749

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.15090	21	0.0071287
Inverse variance weighted	40.26821	22	0.0100574

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019325	0.0078016	0.8067721

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012417	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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