Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 591)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0511374	0.1318401	0.7020129
Weighted median	23	-0.0583500	0.0609412	0.3383256
Inverse variance weighted	23	0.0411094	0.0510332	0.4205071
Simple mode	23	-0.0328358	0.1072970	0.7624613
Weighted mode	23	-0.0550641	0.0688712	0.4325350

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.63404	21	0.0185369
Inverse variance weighted	37.64206	22	0.0200896

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056649	0.0074523	0.4556124

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011742	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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