Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 590)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0942661 0.1051588 0.3801919
Weighted median 23 -0.0962336 0.0579786 0.0969524
Inverse variance weighted 23 -0.0464333 0.0403898 0.2502965
Simple mode 23 -0.1025141 0.1054261 0.3414330
Weighted mode 23 -0.1142999 0.0715077 0.1242121

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.30647 21 0.3278582
Inverse variance weighted 23.57750 22 0.3697589

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0029374 0.0059441 0.6263137

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007574 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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