Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 59)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0802584	0.0998203	0.4303886
Weighted median	23	0.0572156	0.0554812	0.3024187
Inverse variance weighted	23	0.0640624	0.0390154	0.1005950
Simple mode	23	0.1383502	0.0944503	0.1571225
Weighted mode	23	0.0327483	0.0675739	0.6327294

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.57954	21	0.6120922
Inverse variance weighted	18.61061	22	0.6692338

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009946	0.0056423	0.8617678

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006457	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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