Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 589)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0417931	0.1025176	0.6876435
Weighted median	23	0.0739204	0.0605043	0.2218063
Inverse variance weighted	23	0.0567681	0.0391720	0.1472816
Simple mode	23	0.1041864	0.1003866	0.3106123
Weighted mode	23	0.0765687	0.0752939	0.3202405

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.15035	21	0.3908904
Inverse variance weighted	22.17692	22	0.4493722

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009196	0.0057948	0.8754244

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007362	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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