Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 588)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1086508	0.0998211	0.2887284
Weighted median	23	0.0622315	0.0547269	0.2554852
Inverse variance weighted	23	0.0302007	0.0390156	0.4388913
Simple mode	23	0.1018108	0.0927683	0.2843018
Weighted mode	23	0.0535938	0.0647571	0.4167779

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.50571	21	0.6168153
Inverse variance weighted	19.23473	22	0.6307922

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048176	0.0056424	0.4028353

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000601	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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