Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 587)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1283675	0.0998207	0.2124492
Weighted median	23	-0.0551070	0.0570460	0.3340392
Inverse variance weighted	23	-0.0391719	0.0390157	0.3153775
Simple mode	23	-0.0460222	0.0908965	0.6176727
Weighted mode	23	-0.0313033	0.0652820	0.6363089

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.33580	21	0.6905606
Inverse variance weighted	20.66079	22	0.5417777

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0102885	0.0056423	0.0825014

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006566	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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