Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 586)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0112060	0.1070371	0.9176132
Weighted median	23	-0.0482739	0.0564548	0.3925013
Inverse variance weighted	23	0.0193851	0.0408810	0.6353687
Simple mode	23	-0.0788641	0.1023149	0.4490261
Weighted mode	23	-0.0380286	0.0658909	0.5697014

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.14587	21	0.2860444
Inverse variance weighted	24.15380	22	0.3392196

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005023	0.0060502	0.9346237

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007394	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8