Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 585)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1376643	0.1249124	0.2828953
Weighted median	23	-0.0475733	0.0596654	0.4252566
Inverse variance weighted	23	-0.0746760	0.0480403	0.1200781
Simple mode	23	0.0795004	0.0978375	0.4251674
Weighted mode	23	-0.0730179	0.0685690	0.2984773

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.88573	21	0.0474996
Inverse variance weighted	33.35573	22	0.0570421

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038681	0.0070607	0.5895784

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011216	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8