Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 584)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0860541	0.1088818	0.4381611
Weighted median	23	0.0090292	0.0576661	0.8755787
Inverse variance weighted	23	0.0487458	0.0433331	0.2606279
Simple mode	23	-0.0190743	0.0885329	0.8314024
Weighted mode	23	0.0052936	0.0622113	0.9329594

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.98579	21	0.2477802
Inverse variance weighted	27.13828	22	0.2060214

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.008278	0.0061545	0.19296

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008696	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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