Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 583)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1433246	0.0998199	0.1657797
Weighted median	23	-0.0393257	0.0569711	0.4900213
Inverse variance weighted	23	-0.0223894	0.0390155	0.5660623
Simple mode	23	-0.1163701	0.1012519	0.2627689
Weighted mode	23	-0.0352467	0.0791401	0.6604028

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.66399	21	0.6701575
Inverse variance weighted	20.91698	22	0.5258742

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0101765	0.0056423	0.0856601

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006438	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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