Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 582)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0687702	0.1098806	0.5381486
Weighted median	23	0.0124727	0.0592822	0.8333591
Inverse variance weighted	23	0.0393591	0.0420444	0.3492051
Simple mode	23	0.0960096	0.0993866	0.3445337
Weighted mode	23	0.0046680	0.0689624	0.9466451

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.44615	21	0.2283583
Inverse variance weighted	25.54862	22	0.2715655

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018061	0.006211	0.7740599

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000805	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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