Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 581)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1158402	0.1122203	0.3136942
Weighted median	23	-0.0341196	0.0567566	0.5477364
Inverse variance weighted	23	-0.0379579	0.0434300	0.3821172
Simple mode	23	0.0226255	0.0948613	0.8136920
Weighted mode	23	-0.0377184	0.0592740	0.5311206

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.54156	21	0.1865473
Inverse variance weighted	27.26008	22	0.2015143

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047827	0.0063432	0.4592256

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008547	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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