Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 580)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0284649	0.1064962	0.7918565
Weighted median	23	-0.0311240	0.0592637	0.5994595
Inverse variance weighted	23	0.0173384	0.0408786	0.6714612
Simple mode	23	-0.0670425	0.1099402	0.5482359
Weighted mode	23	-0.0790526	0.0837981	0.3557370

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.90330	21	0.2977676
Inverse variance weighted	24.15182	22	0.3393220

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028128	0.0060197	0.6451237

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007378	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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