Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 58)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1231271	0.1208049	0.3196964
Weighted median	23	0.0097852	0.0580118	0.8660515
Inverse variance weighted	23	0.0453015	0.0466669	0.3316775
Simple mode	23	0.0501509	0.0976072	0.6125116
Weighted mode	23	0.0190681	0.0612972	0.7586708

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.75765	21	0.0777870
Inverse variance weighted	31.47513	22	0.0867953

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047792	0.0068284	0.4916696

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009946	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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