Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 579)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0353139	0.1213034	0.7738154
Weighted median	23	-0.0126742	0.0621661	0.8384498
Inverse variance weighted	23	-0.0751715	0.0473899	0.1126864
Simple mode	23	-0.2891600	0.1285407	0.0348155
Weighted mode	23	0.0146130	0.0894585	0.8717348

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.01274	21	0.0734463
Inverse variance weighted	32.45878	22	0.0699038

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067849	0.0068567	0.3336669

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001096	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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