Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 577)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0134721	0.1147990	0.9076950
Weighted median	23	-0.0089811	0.0573205	0.8754957
Inverse variance weighted	23	0.0051929	0.0438710	0.9057772
Simple mode	23	0.0962810	0.1160585	0.4156820
Weighted mode	23	-0.0365310	0.0860314	0.6752352

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.77572	21	0.1466275
Inverse variance weighted	27.81699	22	0.1818258

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011462	0.006489	0.861484

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008434	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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