Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 576)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0023542	0.0998198	0.9814065
Weighted median	23	0.0272813	0.0597191	0.6477949
Inverse variance weighted	23	0.0221549	0.0390154	0.5701378
Simple mode	23	0.0327276	0.1081406	0.7650079
Weighted mode	23	0.0111947	0.0806532	0.8908708

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.34455	21	0.4995410
Inverse variance weighted	20.41570	22	0.5570539

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015051	0.0056423	0.7922609

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006284	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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