Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 575)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0595256	0.0998205	0.5573317
Weighted median	23	-0.0502755	0.0560769	0.3699616
Inverse variance weighted	23	-0.0592672	0.0390157	0.1287478
Simple mode	23	-0.0197454	0.0907974	0.8298485
Weighted mode	23	-0.0317946	0.0657577	0.6335100

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.40424	21	0.4958015
Inverse variance weighted	20.40425	22	0.5577692

Test for directional horizontal pleiotropy

egger_intercept	se	pval
1.59e-05	0.0056423	0.9977825

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006882	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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