Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 574)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0754814	0.1051125	0.4806081
Weighted median	23	-0.0001881	0.0572129	0.9973772
Inverse variance weighted	23	0.0021477	0.0407498	0.9579671
Simple mode	23	0.0466988	0.0940363	0.6243945
Weighted mode	23	0.0222863	0.0621266	0.7232208

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.28542	21	0.3289512
Inverse variance weighted	23.99927	22	0.3472679

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047672	0.0059415	0.4313318

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007273	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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