Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 573)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0214432	0.1200971	0.8600033
Weighted median	23	-0.0476811	0.0577410	0.4089312
Inverse variance weighted	23	0.0000437	0.0459023	0.9992405
Simple mode	23	-0.0477341	0.1055105	0.6554023
Weighted mode	23	-0.0586396	0.0667298	0.3890276

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.39813	21	0.0842747
Inverse variance weighted	30.45238	22	0.1078773

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013141	0.0067884	0.8483617

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009227	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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