Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 572)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0082036	0.1221880	0.9471058
Weighted median	23	-0.0192785	0.0543244	0.7226809
Inverse variance weighted	23	-0.0034320	0.0466718	0.9413800
Simple mode	23	-0.0565631	0.0883422	0.5286081
Weighted mode	23	-0.0149720	0.0572191	0.7960178

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.46555	21	0.0662514
Inverse variance weighted	31.48159	22	0.0866740

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007145	0.0069066	0.9185815

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000954	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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