Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 571)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1582710	0.1010766	0.1323287
Weighted median	23	-0.0559348	0.0539498	0.2998325
Inverse variance weighted	23	-0.0222763	0.0405144	0.5824313
Simple mode	23	-0.0481971	0.0957798	0.6198192
Weighted mode	23	-0.0764251	0.0645555	0.2491000

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.53213	21	0.4268862
Inverse variance weighted	23.72297	22	0.3619166

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0083514	0.0057133	0.1586156

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007287	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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