Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 570)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1874697	0.1265033	0.1532085
Weighted median	23	-0.0400508	0.0636236	0.5290249
Inverse variance weighted	23	0.0463243	0.0499692	0.3538970
Simple mode	23	0.1246122	0.1289868	0.3445023
Weighted mode	23	-0.0482591	0.0899786	0.5971061

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.72870	21	0.0387359
Inverse variance weighted	36.08868	22	0.0297083

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086678	0.0071506	0.2389092

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011362	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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