Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 57)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1003252	0.1214655	0.4181143
Weighted median	23	-0.0803711	0.0564660	0.1546337
Inverse variance weighted	23	-0.0380904	0.0467256	0.4149617
Simple mode	23	-0.1679253	0.1043107	0.1216856
Weighted mode	23	-0.0935564	0.0667534	0.1750083

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.09610	21	0.0720734
Inverse variance weighted	31.55492	22	0.0853070

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038218	0.0068658	0.5836524

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000985	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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