Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 568)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0309808	0.0998196	0.7593401
Weighted median	23	-0.0275808	0.0585160	0.6373992
Inverse variance weighted	23	-0.0186770	0.0390153	0.6321446
Simple mode	23	-0.1166739	0.1142012	0.3180494
Weighted mode	23	-0.0557180	0.0841873	0.5149509

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.90300	21	0.4648816
Inverse variance weighted	21.19511	22	0.5087095

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030495	0.0056423	0.5945591

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006492	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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