Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 567)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2011319	0.1154011	0.0959780
Weighted median	23	0.0501354	0.0576532	0.3845176
Inverse variance weighted	23	0.0232861	0.0469174	0.6196673
Simple mode	23	0.0392132	0.1052046	0.7129144
Weighted mode	23	0.0904347	0.0643367	0.1737948

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.06753	21	0.1382465
Inverse variance weighted	31.81424	22	0.0806186

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0109215	0.006523	0.1089023

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009748	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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