Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 566)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0326557	0.1112998	0.7720939
Weighted median	23	-0.0343925	0.0623908	0.5814678
Inverse variance weighted	23	-0.0647316	0.0426012	0.1286420
Simple mode	23	-0.0443230	0.1075733	0.6843077
Weighted mode	23	-0.0025594	0.0744224	0.9728763

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.10788	21	0.2023653
Inverse variance weighted	26.22976	22	0.2419482

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019698	0.0062912	0.757293

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008782	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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