Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 565)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1154744	0.0998178	0.2603237
Weighted median	23	-0.0014853	0.0631962	0.9812494
Inverse variance weighted	23	0.0280386	0.0390148	0.4723462
Simple mode	23	0.0661207	0.1187825	0.5833833
Weighted mode	23	-0.0494917	0.1217250	0.6882402

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.78972	21	0.4718485
Inverse variance weighted	21.69538	22	0.4781919

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0053695	0.0056423	0.3520965

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000673	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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