Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 564)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0983775	0.0998192	0.3355704
Weighted median	23	0.0247567	0.0540589	0.6469828
Inverse variance weighted	23	0.0483816	0.0390155	0.2149527
Simple mode	23	-0.0329165	0.0929929	0.7267327
Weighted mode	23	0.0160454	0.0657533	0.8094727

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.99376	21	0.6493990
Inverse variance weighted	18.28986	22	0.6886706

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030703	0.0056423	0.5920677

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006008	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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