Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 563)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1396113	0.1070526	0.2063007
Weighted median	23	-0.0225188	0.0619523	0.7162420
Inverse variance weighted	23	0.0115653	0.0431109	0.7884928
Simple mode	23	0.0633074	0.1048950	0.5523280
Weighted mode	23	-0.0384705	0.0783475	0.6282718

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.15396	21	0.2856589
Inverse variance weighted	26.86130	22	0.2165418

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0092838	0.0060511	0.1399048

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008166	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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