Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 562)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1166324	0.1076194	0.2907624
Weighted median	23	0.0549931	0.0589784	0.3511158
Inverse variance weighted	23	0.0673797	0.0413382	0.1031090
Simple mode	23	0.0702105	0.0987195	0.4844258
Weighted mode	23	0.0523547	0.0822150	0.5308246

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.41060	21	0.2735920
Inverse variance weighted	24.69797	22	0.3117352

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030246	0.0060832	0.6242073

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008388	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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