Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 561)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0301881	0.1102775	0.7869537
Weighted median	23	0.0253963	0.0556640	0.6482147
Inverse variance weighted	23	-0.0006853	0.0422044	0.9870440
Simple mode	23	0.0461059	0.0820102	0.5796654
Weighted mode	23	0.0257200	0.0588382	0.6662769

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.63003	21	0.2209085
Inverse variance weighted	25.74294	22	0.2628825

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018959	0.0062334	0.764002

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007801	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8