Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 560)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0034431	0.1065508	0.9745269
Weighted median	23	0.0597498	0.0547313	0.2749679
Inverse variance weighted	23	0.0218134	0.0407227	0.5921952
Simple mode	23	0.0209116	0.0937067	0.8254698
Weighted mode	23	0.0637447	0.0617517	0.3131593

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.92744	21	0.2965875
Inverse variance weighted	23.96742	22	0.3489397

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011281	0.0060228	0.8532158

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007357	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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