Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 56)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0548639	0.0998202	0.5883729
Weighted median	23	0.0118834	0.0564468	0.8332588
Inverse variance weighted	23	-0.0316244	0.0390154	0.4176176
Simple mode	23	0.0982849	0.1010287	0.3412075
Weighted mode	23	0.0440938	0.0724311	0.5489127

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.33569	21	0.6276731
Inverse variance weighted	18.39967	22	0.6820466

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014271	0.0056423	0.8027781

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005775	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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