Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 558)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1052854	0.1052101	0.3283564
Weighted median	23	0.0674854	0.0555514	0.2244316
Inverse variance weighted	23	0.0380308	0.0406356	0.3493255
Simple mode	23	0.0650995	0.1007429	0.5248378
Weighted mode	23	0.0617205	0.0646989	0.3504665

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.32898	21	0.3266918
Inverse variance weighted	23.86478	22	0.3543570

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041301	0.005947	0.494989

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000752	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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