Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 557)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1496888	0.1045834	0.1670628
Weighted median	23	-0.0340077	0.0575193	0.5543599
Inverse variance weighted	23	0.0417138	0.0435345	0.3379734
Simple mode	23	-0.0164531	0.0903450	0.8571610
Weighted mode	23	-0.0455426	0.0586161	0.4454545

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.05192	21	0.3412163
Inverse variance weighted	27.39158	22	0.1967298

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0117539	0.0059115	0.0599681

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008646	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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