Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 556)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0399087	0.1208343	0.7444638
Weighted median	23	-0.0555571	0.0555144	0.3169385
Inverse variance weighted	23	0.0136030	0.0462044	0.7684449
Simple mode	23	-0.0453609	0.1029451	0.6637791
Weighted mode	23	-0.0279381	0.0651363	0.6721536

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.77246	21	0.0775290
Inverse variance weighted	30.85443	22	0.0991329

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016154	0.0068301	0.8153253

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009386	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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